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Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients
BACKGROUND: Tumor markers (TMs) are important for the prognosis of gastric cancer (GC). However, the prognostic importance of the tumor marker index (TMI) based on GC-specific TMs for advanced gastric cancer (AGC) still needs to be further explored. METHODS: We retrospectively examined patients who...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515535/ https://www.ncbi.nlm.nih.gov/pubmed/37728233 http://dx.doi.org/10.1177/10732748231202466 |
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author | Zhang, Jiaqi Yin, Xin Wang, Hao Fang, Tianyi Gao, Jialiang Zhu, Ziyu Li, Chunfeng Wang, Yufei Wang, Xibo Lu, Zhanfei Wu, Junpeng Wang, Yimin Zhang, Yao Xue, Yingwei |
author_facet | Zhang, Jiaqi Yin, Xin Wang, Hao Fang, Tianyi Gao, Jialiang Zhu, Ziyu Li, Chunfeng Wang, Yufei Wang, Xibo Lu, Zhanfei Wu, Junpeng Wang, Yimin Zhang, Yao Xue, Yingwei |
author_sort | Zhang, Jiaqi |
collection | PubMed |
description | BACKGROUND: Tumor markers (TMs) are important for the prognosis of gastric cancer (GC). However, the prognostic importance of the tumor marker index (TMI) based on GC-specific TMs for advanced gastric cancer (AGC) still needs to be further explored. METHODS: We retrospectively examined patients who underwent radical gastric cancer surgery between February 2014 and June 2016 at the Department of Gastroenterological Surgery, Affiliated Cancer Hospital, Harbin Medical University. The patients were divided into training and validation groups. TMI was determined as the geometric mean of the standard cancer antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels. Patient overall survival was assessed using the Kaplan–Meier method. Independent prognosis-associated risk factors were identified using Cox hazard regression models. A nomogram model incorporating TMI and clinicopathological factors was developed, and its performance was evaluated using a decision curve analysis, concordance index, and calibration plots. RESULTS: In the TMI training cohort, the cutoff value was set at .439, categorizing patients into TMI-High and TMI-Low groups. The 5-year survival rate in the TMI-Low group significantly surpassed that in the TMI-High group (78.2% vs 58.1% and 49.7 vs 41.6, P < .001). TMI emerged as an independent prognostic factor. The nomogram accurately predicted patient prognosis by using TMI and clinicopathological characteristics. Validation of the TMI in the independent cohort yielded satisfactory results. CONCLUSION: The TMI constructed based on specific TMs associated with gastric cancer can offer a precise prognostic prediction for patients. |
format | Online Article Text |
id | pubmed-10515535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-105155352023-09-23 Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients Zhang, Jiaqi Yin, Xin Wang, Hao Fang, Tianyi Gao, Jialiang Zhu, Ziyu Li, Chunfeng Wang, Yufei Wang, Xibo Lu, Zhanfei Wu, Junpeng Wang, Yimin Zhang, Yao Xue, Yingwei Cancer Control Original Research Article BACKGROUND: Tumor markers (TMs) are important for the prognosis of gastric cancer (GC). However, the prognostic importance of the tumor marker index (TMI) based on GC-specific TMs for advanced gastric cancer (AGC) still needs to be further explored. METHODS: We retrospectively examined patients who underwent radical gastric cancer surgery between February 2014 and June 2016 at the Department of Gastroenterological Surgery, Affiliated Cancer Hospital, Harbin Medical University. The patients were divided into training and validation groups. TMI was determined as the geometric mean of the standard cancer antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) levels. Patient overall survival was assessed using the Kaplan–Meier method. Independent prognosis-associated risk factors were identified using Cox hazard regression models. A nomogram model incorporating TMI and clinicopathological factors was developed, and its performance was evaluated using a decision curve analysis, concordance index, and calibration plots. RESULTS: In the TMI training cohort, the cutoff value was set at .439, categorizing patients into TMI-High and TMI-Low groups. The 5-year survival rate in the TMI-Low group significantly surpassed that in the TMI-High group (78.2% vs 58.1% and 49.7 vs 41.6, P < .001). TMI emerged as an independent prognostic factor. The nomogram accurately predicted patient prognosis by using TMI and clinicopathological characteristics. Validation of the TMI in the independent cohort yielded satisfactory results. CONCLUSION: The TMI constructed based on specific TMs associated with gastric cancer can offer a precise prognostic prediction for patients. SAGE Publications 2023-09-20 /pmc/articles/PMC10515535/ /pubmed/37728233 http://dx.doi.org/10.1177/10732748231202466 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Zhang, Jiaqi Yin, Xin Wang, Hao Fang, Tianyi Gao, Jialiang Zhu, Ziyu Li, Chunfeng Wang, Yufei Wang, Xibo Lu, Zhanfei Wu, Junpeng Wang, Yimin Zhang, Yao Xue, Yingwei Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title | Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title_full | Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title_fullStr | Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title_full_unstemmed | Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title_short | Development and Validation of Tumor Marker Indices in Advanced Gastric Cancer Patients |
title_sort | development and validation of tumor marker indices in advanced gastric cancer patients |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515535/ https://www.ncbi.nlm.nih.gov/pubmed/37728233 http://dx.doi.org/10.1177/10732748231202466 |
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