Mechanism-Based Redesign of GAP to Activate Oncogenic Ras

[Image: see text] Ras GTPases play a crucial role in cell signaling pathways. Mutations of the Ras gene occur in about one third of cancerous cell lines and are often associated with detrimental clinical prognosis. Hot spot residues Gly12, Gly13, and Gln61 cover 97% of oncogenic mutations, which imp...

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Detalles Bibliográficos
Autores principales: Berta, Dénes, Gehrke, Sascha, Nyíri, Kinga, Vértessy, Beáta G., Rosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515638/
https://www.ncbi.nlm.nih.gov/pubmed/37682266
http://dx.doi.org/10.1021/jacs.3c04330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515638/
https://www.ncbi.nlm.nih.gov/pubmed/37682266
http://dx.doi.org/10.1021/jacs.3c04330

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