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Mechanism-Based Redesign of GAP to Activate Oncogenic Ras
[Image: see text] Ras GTPases play a crucial role in cell signaling pathways. Mutations of the Ras gene occur in about one third of cancerous cell lines and are often associated with detrimental clinical prognosis. Hot spot residues Gly12, Gly13, and Gln61 cover 97% of oncogenic mutations, which imp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515638/ https://www.ncbi.nlm.nih.gov/pubmed/37682266 http://dx.doi.org/10.1021/jacs.3c04330 |