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Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis

[Image: see text] Documenting the occurrence of viruses on fomites is crucial in determining the significance of fomite-mediated transmission and the potential use of fomites for environmental disease surveillance. We conducted a systematic review and meta-analysis to compile information on the occu...

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Autores principales: Zambrana, Winnie, Boehm, Alexandria B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515712/
https://www.ncbi.nlm.nih.gov/pubmed/37743950
http://dx.doi.org/10.1021/acsenvironau.3c00025
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author Zambrana, Winnie
Boehm, Alexandria B.
author_facet Zambrana, Winnie
Boehm, Alexandria B.
author_sort Zambrana, Winnie
collection PubMed
description [Image: see text] Documenting the occurrence of viruses on fomites is crucial in determining the significance of fomite-mediated transmission and the potential use of fomites for environmental disease surveillance. We conducted a systematic review and meta-analysis to compile information on the occurrence of human viruses on fomites in the environment; we identified 134 peer-reviewed papers. We compiled sampling and measurement methods, results, quality control information, and whether virus data were compared with community health data from the papers. We conducted univariate and multivariate analyses to investigate if presence of virus on fomites was associated with virus type (enveloped, nonenveloped), sampling location (healthcare setting, nonhealthcare temporary setting, nonhealthcare nontemporary setting), and area of fomite swabbed (<50, 50–100, >100 cm(2)). Across 275 data sets from the 134 papers, there was the most data available for Coronaviridae and from fomites at hospitals. Positivity rates, defined as the percent positive fomite samples, were low (median = 6%). Data were available on viruses from 16 different viral families, but data on viruses from 9 families had few (n < 5) data sets. Many human virus families were not identified in this review (11 families). Less than 15% of the data sets reported virus concentrations in externally valid units (viruses per area of surface), and 16% provided a quantitative comparison between virus and health data. Virus type and area swabbed were significant predictors of virus presence on fomites, and the positivity rate of data sets collected from healthcare settings and nonhealthcare nontemporary settings (e.g., individual housing) were significantly higher than those collected in nonhealthcare temporary settings (e.g., restaurants). Data from this review indicates that viruses may be present on fomites, that fomite-mediated virus transmission may occur, and that fomites may provide information on circulation of infectious diseases in the community. However, more quantitative data on diverse viruses are needed, and method reporting needs significant improvements.
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spelling pubmed-105157122023-09-23 Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis Zambrana, Winnie Boehm, Alexandria B. ACS Environ Au [Image: see text] Documenting the occurrence of viruses on fomites is crucial in determining the significance of fomite-mediated transmission and the potential use of fomites for environmental disease surveillance. We conducted a systematic review and meta-analysis to compile information on the occurrence of human viruses on fomites in the environment; we identified 134 peer-reviewed papers. We compiled sampling and measurement methods, results, quality control information, and whether virus data were compared with community health data from the papers. We conducted univariate and multivariate analyses to investigate if presence of virus on fomites was associated with virus type (enveloped, nonenveloped), sampling location (healthcare setting, nonhealthcare temporary setting, nonhealthcare nontemporary setting), and area of fomite swabbed (<50, 50–100, >100 cm(2)). Across 275 data sets from the 134 papers, there was the most data available for Coronaviridae and from fomites at hospitals. Positivity rates, defined as the percent positive fomite samples, were low (median = 6%). Data were available on viruses from 16 different viral families, but data on viruses from 9 families had few (n < 5) data sets. Many human virus families were not identified in this review (11 families). Less than 15% of the data sets reported virus concentrations in externally valid units (viruses per area of surface), and 16% provided a quantitative comparison between virus and health data. Virus type and area swabbed were significant predictors of virus presence on fomites, and the positivity rate of data sets collected from healthcare settings and nonhealthcare nontemporary settings (e.g., individual housing) were significantly higher than those collected in nonhealthcare temporary settings (e.g., restaurants). Data from this review indicates that viruses may be present on fomites, that fomite-mediated virus transmission may occur, and that fomites may provide information on circulation of infectious diseases in the community. However, more quantitative data on diverse viruses are needed, and method reporting needs significant improvements. American Chemical Society 2023-07-25 /pmc/articles/PMC10515712/ /pubmed/37743950 http://dx.doi.org/10.1021/acsenvironau.3c00025 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Zambrana, Winnie
Boehm, Alexandria B.
Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title_full Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title_fullStr Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title_full_unstemmed Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title_short Occurrence of Human Viruses on Fomites in the Environment: A Systematic Review and Meta-analysis
title_sort occurrence of human viruses on fomites in the environment: a systematic review and meta-analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515712/
https://www.ncbi.nlm.nih.gov/pubmed/37743950
http://dx.doi.org/10.1021/acsenvironau.3c00025
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