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Homeostatic role of B-1 cells in tissue immunity

To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavities and distinct from conventional B-2 cells in th...

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Detalles Bibliográficos
Autores principales: Suchanek, Ondrej, Clatworthy, Menna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515722/
https://www.ncbi.nlm.nih.gov/pubmed/37744333
http://dx.doi.org/10.3389/fimmu.2023.1106294
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author Suchanek, Ondrej
Clatworthy, Menna R.
author_facet Suchanek, Ondrej
Clatworthy, Menna R.
author_sort Suchanek, Ondrej
collection PubMed
description To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavities and distinct from conventional B-2 cells in their ontogeny, phenotype and function. Here we discuss how B-1 cells represent exemplar tissue-resident immune cells, summarizing the evidence for their long-term persistence & self-renewal within tissues, differential transcriptional programming shaped by organ-specific environmental cues, as well as their tissue-homeostatic functions. Finally, we review the emerging data supporting the presence and homeostatic role of B-1 cells across non-lymphoid organs (NLOs) both in mouse and human.
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spelling pubmed-105157222023-09-23 Homeostatic role of B-1 cells in tissue immunity Suchanek, Ondrej Clatworthy, Menna R. Front Immunol Immunology To date, studies of tissue-resident immunity have mainly focused on innate immune cells and T cells, with limited data on B cells. B-1 B cells are a unique subset of B cells with innate-like properties, enriched in murine pleural and peritoneal cavities and distinct from conventional B-2 cells in their ontogeny, phenotype and function. Here we discuss how B-1 cells represent exemplar tissue-resident immune cells, summarizing the evidence for their long-term persistence & self-renewal within tissues, differential transcriptional programming shaped by organ-specific environmental cues, as well as their tissue-homeostatic functions. Finally, we review the emerging data supporting the presence and homeostatic role of B-1 cells across non-lymphoid organs (NLOs) both in mouse and human. Frontiers Media S.A. 2023-09-08 /pmc/articles/PMC10515722/ /pubmed/37744333 http://dx.doi.org/10.3389/fimmu.2023.1106294 Text en Copyright © 2023 Suchanek and Clatworthy https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Suchanek, Ondrej
Clatworthy, Menna R.
Homeostatic role of B-1 cells in tissue immunity
title Homeostatic role of B-1 cells in tissue immunity
title_full Homeostatic role of B-1 cells in tissue immunity
title_fullStr Homeostatic role of B-1 cells in tissue immunity
title_full_unstemmed Homeostatic role of B-1 cells in tissue immunity
title_short Homeostatic role of B-1 cells in tissue immunity
title_sort homeostatic role of b-1 cells in tissue immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515722/
https://www.ncbi.nlm.nih.gov/pubmed/37744333
http://dx.doi.org/10.3389/fimmu.2023.1106294
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