Cargando…

Hybrid deep modeling of a CHO-K1 fed-batch process: combining first-principles with deep neural networks

Introduction: Hybrid modeling combining First-Principles with machine learning is becoming a pivotal methodology for Biopharma 4.0 enactment. Chinese Hamster Ovary (CHO) cells, being the workhorse for industrial glycoproteins production, have been the object of several hybrid modeling studies. Most...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinto, José, Ramos, João R. C., Costa, Rafael S., Rossell, Sergio, Dumas, Patrick, Oliveira, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515724/ https://www.ncbi.nlm.nih.gov/pubmed/37744245 http://dx.doi.org/10.3389/fbioe.2023.1237963

Ejemplares similares

Model-based intensification of CHO cell cultures: One-step strategy from fed-batch to perfusion
por: Richelle, Anne, et al.
Publicado: (2022)

The Rocky Road From Fed-Batch to Continuous Processing With E. coli
por: Kopp, Julian, et al.
Publicado: (2019)

Efficient biosynthesis of exopolysaccharide in Candida glabrata by a fed-batch culture
por: Xu, Sha, et al.
Publicado: (2022)

Repetitive Fed-Batch: A Promising Process Mode for Biomanufacturing With E. coli
por: Kopp, Julian, et al.
Publicado: (2020)

Boosting Recombinant Inclusion Body Production—From Classical Fed-Batch Approach to Continuous Cultivation
por: Kopp, Julian, et al.
Publicado: (2019)

Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUT(s) Strain
por: Rodrigues, David, et al.
Publicado: (2019)

Optimization and Kinetic Modeling of a Fed-Batch Fermentation for Mannosylerythritol Lipids (MEL) Production With Moesziomyces aphidis
por: Beck, Alexander, et al.
Publicado: (2022)

Metabolic characterization of a CHO cell size increase phase in fed-batch cultures
por: Pan, Xiao, et al.
Publicado: (2017)

Optimizing a Fed-Batch High-Density Fermentation Process for Medium Chain-Length Poly(3-Hydroxyalkanoates) in Escherichia coli
por: Scheel, Ryan A., et al.
Publicado: (2021)

A Novel Hybrid Deep Neural Network to Predict Pre-impact Fall for Older People Based on Wearable Inertial Sensors
por: Yu, Xiaoqun, et al.
Publicado: (2020)

Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy
por: Martínez, Juan A., et al.
Publicado: (2020)

Fed-Batch mcl- Polyhydroxyalkanoates Production in Pseudomonas putida KT2440 and ΔphaZ Mutant on Biodiesel-Derived Crude Glycerol
por: Borrero-de Acuña, José Manuel, et al.
Publicado: (2021)

Photoelastic Stress Field Recovery Using Deep Convolutional Neural Network
por: Tao, Bo, et al.
Publicado: (2022)

Fed-Batch Cultivations of Rhodospirillum rubrum Under Multiple Nutrient-Limited Growth Conditions on Syngas as a Novel Option to Produce Poly(3-Hydroxybutyrate) (PHB)
por: Karmann, Stephanie, et al.
Publicado: (2019)

Two-Stage Deep Neural Network via Ensemble Learning for Melanoma Classification
por: Ding, Jiaqi, et al.
Publicado: (2022)

Decoupling Growth and Protein Production in CHO Cells: A Targeted Approach
por: Donaldson, James S., et al.
Publicado: (2021)

Enhanced Transgene Expression by Optimization of Poly A in Transfected CHO Cells
por: Wang, Xiao-yin, et al.
Publicado: (2022)

Substrate-Flexible Two-Stage Fed-Batch Cultivations for the Production of the PHA Copolymer P(HB-co-HHx) With Cupriavidus necator Re2058/pCB113
por: Santolin, Lara, et al.
Publicado: (2021)

Staining Invariant Features for Improving Generalization of Deep Convolutional Neural Networks in Computational Pathology
por: Otálora, Sebastian, et al.
Publicado: (2019)

Sensor Data Required for Automatic Recognition of Athletic Tasks Using Deep Neural Networks
por: Clouthier, Allison L., et al.
Publicado: (2020)

Rapid intensification of an established CHO cell fed‐batch process
por: Schulze, Markus, et al.
Publicado: (2021)

Growth and eGFP Production of CHO-K1 Suspension Cells Cultivated From Single Cell to Laboratory Scale
por: Schmitz, Julian, et al.
Publicado: (2021)

The Effect of microRNA on the Production of Recombinant Protein in CHO Cells and its Mechanism
por: Liu, Hui-Ning, et al.
Publicado: (2022)

Engineering protein glycosylation in CHO cells to be highly similar to murine host cells
por: Gupta, Shivani, et al.
Publicado: (2023)

A Multichannel Deep Neural Network for Retina Vessel Segmentation via a Fusion Mechanism
por: Ding, Jiaqi, et al.
Publicado: (2021)

Classification of 41 Hand and Wrist Movements via Surface Electromyogram Using Deep Neural Network
por: Sri-iesaranusorn, Panyawut, et al.
Publicado: (2021)

RA-UNet: A Hybrid Deep Attention-Aware Network to Extract Liver and Tumor in CT Scans
por: Jin, Qiangguo, et al.
Publicado: (2020)

Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells
por: Li, Qin, et al.
Publicado: (2022)

Automated segmentation of vertebral cortex with 3D U-Net-based deep convolutional neural network
por: Li, Yang, et al.
Publicado: (2022)

Combining 3D skeleton data and deep convolutional neural network for balance assessment during walking
por: Ma, Xiangyuan, et al.
Publicado: (2023)

Functional Trimeric SARS-CoV-2 Envelope Protein Expressed in Stable CHO Cells
por: Mayrhofer, Patrick, et al.
Publicado: (2021)

Mechanistic insights into the biological activity of S-Sulfocysteine in CHO cells using a multi-omics approach
por: Nguyen, Melanie, et al.
Publicado: (2023)

Progress in fed-batch culture for recombinant protein production in CHO cells
por: Xu, Wen-Jing, et al.
Publicado: (2023)

DeepSnap-Deep Learning Approach Predicts Progesterone Receptor Antagonist Activity With High Performance
por: Matsuzaka, Yasunari, et al.
Publicado: (2020)

Selection of biophysically favorable antibody variants using a modified Flp-In CHO mammalian display platform
por: Huhtinen, Olli, et al.
Publicado: (2023)

Smooth and accurate predictions of joint contact force time-series in gait using over parameterised deep neural networks
por: Liew, Bernard X. W., et al.
Publicado: (2023)

The Feasibility of Using Acoustic Markers of Speech for Optimizing Patient Outcomes during Randomized Amplitude Variation in Deep Brain Stimulation: A Proof of Principle Methods Study
por: Vogel, Adam P., et al.
Publicado: (2015)

Enhancing and stabilizing monoclonal antibody production by Chinese hamster ovary (CHO) cells with optimized perfusion culture strategies
por: Liang, Kexue, et al.
Publicado: (2023)

Numerical Simulation and Deep Neural Network Revealed Drag Reduction of Microstructured Three-Dimensional Square Cylinders at High Reynolds Numbers
por: Wang, Siying, et al.
Publicado: (2022)

Deep Learning With Sampling in Colon Cancer Histology
por: Shapcott, Mary, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ekejv13a5jeqte4dblg14fbpnj