A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance

Piperaquine (PPQ) is widely used in combination with dihydroartemisinin (DHA) as a first-line treatment against malaria parasites. Multiple genetic drivers of PPQ resistance have been reported, including mutations in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and increased...

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Detalles Bibliográficos
Autores principales: Kane, John, Li, Xue, Kumar, Sudhir, Button-Simons, Katrina A., Brenneman, Katelyn M. Vendrely, Dahlhoff, Haley, Sievert, Mackenzie A.C., Checkley, Lisa A., Shoue, Douglas A., Singh, Puspendra P., Abatiyow, Biley A., Haile, Meseret T., Nair, Shalini, Reyes, Ann, Tripura, Rupam, Peto, Tom, Lek, Dysoley, Kappe, Stefan H.I., Dhorda, Mehul, Nkhoma, Standwell C, Cheeseman, Ian H., Vaughan, Ashley M., Anderson, Timothy J. C., Ferdig, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515748/
https://www.ncbi.nlm.nih.gov/pubmed/37745488
http://dx.doi.org/10.1101/2023.06.06.543862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515748/
https://www.ncbi.nlm.nih.gov/pubmed/37745488
http://dx.doi.org/10.1101/2023.06.06.543862

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