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The activation of INF2 by Piezo1/Ca(2+) is required for mesenchymal to amoeboid transition in confined environments

To invade heterogenous tissues, transformed cells may undergo a mesenchymal to amoeboid transition (MAT). However, the molecular mechanisms regulating this transition are poorly defined. In invasive melanoma cells, we demonstrate that intracellular [Ca(2+)] increases with the degree of confinement i...

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Detalles Bibliográficos
Autores principales: Kar, Neelakshi, Caruso, Alexa P., Prokopiou, Nicos, Logue, Jeremy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515767/
https://www.ncbi.nlm.nih.gov/pubmed/37745412
http://dx.doi.org/10.1101/2023.06.23.546346

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