Structure-based discovery of CFTR potentiators and inhibitors

The cystic fibrosis transmembrane conductance regulator (CFTR) is a crucial ion channel whose loss of function leads to cystic fibrosis, while its hyperactivation leads to secretory diarrhea. Small molecules that improve CFTR folding (correctors) or function (potentiators) are clinically available....

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Detalles Bibliográficos
Autores principales: Liu, Fangyu, Kaplan, Anat Levit, Levring, Jesper, Einsiedel, Jürgen, Tiedt, Stephanie, Distler, Katharina, Omattage, Natalie S., Kondratov, Ivan S., Moroz, Yurii S., Pietz, Harlan L., Irwin, John J., Gmeiner, Peter, Shoichet, Brian K., Chen, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515777/
https://www.ncbi.nlm.nih.gov/pubmed/37745391
http://dx.doi.org/10.1101/2023.09.09.557002

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