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Towards Preclinical Validation of Arbaclofen (R-baclofen) Treatment for 16p11.2 Deletion Syndrome

A microdeletion on human chromosome 16p11.2 is one of the most common copy number variants associated with autism spectrum disorder and other neurodevelopmental disabilities. Arbaclofen, a GABA(B) receptor agonist, is a component of racemic baclofen, which is FDA-approved for treating spasticity, an...

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Detalles Bibliográficos
Autores principales:	Gundersen, Brigitta B., O’Brien, William T., Schaffler, Melanie D., Schultz, Maria N., Tsukahara, Tatsuya, Lorenzo, Sandra Martin, Nalesso, Valerie, Luo Clayton, Alice H., Abel, Ted, Crawley, Jacqueline N., Datta, Sandeep Robert, Herault, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515778/ https://www.ncbi.nlm.nih.gov/pubmed/37745360 http://dx.doi.org/10.1101/2023.05.01.538987

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