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Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior

Programmed cell death is a common feature of animal development. During development of the C. elegans hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly in neuronal lineages. Blocking cell death results in supernumerary “undead” neuron...

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Detalles Bibliográficos
Autores principales: Kochersberger, Alison, Torkashvand, Mohammad Mahdi, Lee, Dongyeop, Baskoylu, Saba, Sengupta, Titas, Koonce, Noelle, Emerson, Chloe E., Patel, Nandan V., Colón-Ramos, Daniel, Flavell, Steven, Horvitz, H. Robert, Venkatachalam, Vivek, Hammarlund, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515839/
https://www.ncbi.nlm.nih.gov/pubmed/37745399
http://dx.doi.org/10.1101/2023.09.11.557249
Descripción
Sumario:Programmed cell death is a common feature of animal development. During development of the C. elegans hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly in neuronal lineages. Blocking cell death results in supernumerary “undead” neurons. We find that undead neurons can be wired into circuits, can display activity, and can modify specific behaviors. The two undead RIM-like neurons participate in the RIM-containing circuit that computes movement. The addition of these two extra neurons results in animals that initiate fewer reversals and lengthens the duration of those reversals that do occur. We describe additional behavioral alterations of cell-death mutants, including in turning angle and pharyngeal pumping. These findings reveal that, like too much PCD, too little PCD can modify nervous system function and animal behavior.