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Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior
Programmed cell death is a common feature of animal development. During development of the C. elegans hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly in neuronal lineages. Blocking cell death results in supernumerary “undead” neuron...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515839/ https://www.ncbi.nlm.nih.gov/pubmed/37745399 http://dx.doi.org/10.1101/2023.09.11.557249 |
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author | Kochersberger, Alison Torkashvand, Mohammad Mahdi Lee, Dongyeop Baskoylu, Saba Sengupta, Titas Koonce, Noelle Emerson, Chloe E. Patel, Nandan V. Colón-Ramos, Daniel Flavell, Steven Horvitz, H. Robert Venkatachalam, Vivek Hammarlund, Marc |
author_facet | Kochersberger, Alison Torkashvand, Mohammad Mahdi Lee, Dongyeop Baskoylu, Saba Sengupta, Titas Koonce, Noelle Emerson, Chloe E. Patel, Nandan V. Colón-Ramos, Daniel Flavell, Steven Horvitz, H. Robert Venkatachalam, Vivek Hammarlund, Marc |
author_sort | Kochersberger, Alison |
collection | PubMed |
description | Programmed cell death is a common feature of animal development. During development of the C. elegans hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly in neuronal lineages. Blocking cell death results in supernumerary “undead” neurons. We find that undead neurons can be wired into circuits, can display activity, and can modify specific behaviors. The two undead RIM-like neurons participate in the RIM-containing circuit that computes movement. The addition of these two extra neurons results in animals that initiate fewer reversals and lengthens the duration of those reversals that do occur. We describe additional behavioral alterations of cell-death mutants, including in turning angle and pharyngeal pumping. These findings reveal that, like too much PCD, too little PCD can modify nervous system function and animal behavior. |
format | Online Article Text |
id | pubmed-10515839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105158392023-09-23 Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior Kochersberger, Alison Torkashvand, Mohammad Mahdi Lee, Dongyeop Baskoylu, Saba Sengupta, Titas Koonce, Noelle Emerson, Chloe E. Patel, Nandan V. Colón-Ramos, Daniel Flavell, Steven Horvitz, H. Robert Venkatachalam, Vivek Hammarlund, Marc bioRxiv Article Programmed cell death is a common feature of animal development. During development of the C. elegans hermaphrodite, programmed cell death (PCD) removes 131 cells from stereotyped positions in the cell lineage, mostly in neuronal lineages. Blocking cell death results in supernumerary “undead” neurons. We find that undead neurons can be wired into circuits, can display activity, and can modify specific behaviors. The two undead RIM-like neurons participate in the RIM-containing circuit that computes movement. The addition of these two extra neurons results in animals that initiate fewer reversals and lengthens the duration of those reversals that do occur. We describe additional behavioral alterations of cell-death mutants, including in turning angle and pharyngeal pumping. These findings reveal that, like too much PCD, too little PCD can modify nervous system function and animal behavior. Cold Spring Harbor Laboratory 2023-09-25 /pmc/articles/PMC10515839/ /pubmed/37745399 http://dx.doi.org/10.1101/2023.09.11.557249 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. |
spellingShingle | Article Kochersberger, Alison Torkashvand, Mohammad Mahdi Lee, Dongyeop Baskoylu, Saba Sengupta, Titas Koonce, Noelle Emerson, Chloe E. Patel, Nandan V. Colón-Ramos, Daniel Flavell, Steven Horvitz, H. Robert Venkatachalam, Vivek Hammarlund, Marc Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title | Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title_full | Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title_fullStr | Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title_full_unstemmed | Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title_short | Programmed Cell Death Modifies Neural Circuits and Tunes Intrinsic Behavior |
title_sort | programmed cell death modifies neural circuits and tunes intrinsic behavior |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515839/ https://www.ncbi.nlm.nih.gov/pubmed/37745399 http://dx.doi.org/10.1101/2023.09.11.557249 |
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