The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

Allosteric cooperativity between ATP and substrates is a prominent characteristic of the cAMP-dependent catalytic (C) subunit of protein kinase A (PKA). Not only this long-range synergistic action is involved in substrate recognition and fidelity, but it is likely to regulate PKA association with re...

Descripción completa

Detalles Bibliográficos
Autores principales: Olivieri, Cristina, Wang, Yingjie, Walker, Caitlin, Subrahmanian, Manu V., Ha, Kim N., Bernlohr, David A., Gao, Jiali, Camilloni, Carlo, Vendruscolo, Michele, Taylor, Susan S., Veglia, Gianluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515842/
https://www.ncbi.nlm.nih.gov/pubmed/37745542
http://dx.doi.org/10.1101/2023.09.12.557419

Ejemplares similares

Ejemplares similares