Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses

The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent versus separate administration of these vaccines remains unclear. Here, we analyzed antibody responses in healthcare workers who...

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Autores principales: Barouch, Susanna E., Chicz, Taras M., Blanc, Ross, Barbati, Domenic R., Parker, Lily J., Tong, Xin, McNamara, Ryan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515870/
https://www.ncbi.nlm.nih.gov/pubmed/37745590
http://dx.doi.org/10.1101/2023.09.12.557347
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author Barouch, Susanna E.
Chicz, Taras M.
Blanc, Ross
Barbati, Domenic R.
Parker, Lily J.
Tong, Xin
McNamara, Ryan P.
author_facet Barouch, Susanna E.
Chicz, Taras M.
Blanc, Ross
Barbati, Domenic R.
Parker, Lily J.
Tong, Xin
McNamara, Ryan P.
author_sort Barouch, Susanna E.
collection PubMed
description The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent versus separate administration of these vaccines remains unclear. Here, we analyzed antibody responses in healthcare workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or different days. IgG1 responses to SARS-CoV-2 Spike were higher at peak immunogenicity and 6 months following concurrent administration compared with separate administration of the COVID-19 and influenza vaccines. These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 antibody responses.
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spelling pubmed-105158702023-09-23 Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses Barouch, Susanna E. Chicz, Taras M. Blanc, Ross Barbati, Domenic R. Parker, Lily J. Tong, Xin McNamara, Ryan P. bioRxiv Article The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent versus separate administration of these vaccines remains unclear. Here, we analyzed antibody responses in healthcare workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or different days. IgG1 responses to SARS-CoV-2 Spike were higher at peak immunogenicity and 6 months following concurrent administration compared with separate administration of the COVID-19 and influenza vaccines. These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 antibody responses. Cold Spring Harbor Laboratory 2023-09-12 /pmc/articles/PMC10515870/ /pubmed/37745590 http://dx.doi.org/10.1101/2023.09.12.557347 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Barouch, Susanna E.
Chicz, Taras M.
Blanc, Ross
Barbati, Domenic R.
Parker, Lily J.
Tong, Xin
McNamara, Ryan P.
Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title_full Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title_fullStr Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title_full_unstemmed Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title_short Concurrent administration of COVID-19 and influenza vaccines enhances Spike-specific antibody responses
title_sort concurrent administration of covid-19 and influenza vaccines enhances spike-specific antibody responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515870/
https://www.ncbi.nlm.nih.gov/pubmed/37745590
http://dx.doi.org/10.1101/2023.09.12.557347
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