Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment

Three-dimensional (3D) in vitro models are essential in cancer research, but they often neglect physical forces. In our study, we combined patient-derived tumor organoids with a microfluidic organ-on-chip system to investigate colorectal cancer (CRC) invasion in the tumor microenvironment (TME). Thi...

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Detalles Bibliográficos
Autores principales: Strelez, Carly, Perez, Rachel, Chlystek, John S., Cherry, Christopher, Yoon, Ah Young, Haliday, Bethany, Shah, Curran, Ghaffarian, Kimya, Sun, Ren X., Jiang, Hannah, Lau, Roy, Schatz, Aaron, Lenz, Heinz-Josef, Katz, Jonathan E., Mumenthaler, Shannon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515884/
https://www.ncbi.nlm.nih.gov/pubmed/37745376
http://dx.doi.org/10.1101/2023.09.14.557797

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