CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia

Increased endothelial cell (EC) proliferation is a hallmark of arteriovenous malformations (AVMs) in hereditary hemorrhagic telangiectasia (HHT). The underlying mechanism and disease relevance of this abnormal cell proliferative state of the ECs remain unknown. Here, we report the identification of...

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Detalles Bibliográficos
Autores principales: Dinakaran, Sajeth, Zhao, Haitian, Tang, Yuefeng, Wang, Zhimin, Ruiz, Santiago, Nomura-Kitabayashi, Aya, Blanc, Lionel, Faughnan, Marie E., Marambaud, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515892/
https://www.ncbi.nlm.nih.gov/pubmed/37745444
http://dx.doi.org/10.1101/2023.09.15.554413

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