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Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2

INTRODUCTION: Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene cause autosomal dominant Parkinson’s disease (PD) with the most common causative mutation being the LRRK2 p.G2019S within the kinase domain. LRRK2 protein is highly expressed in the human brain and also in the periphery, and hi...

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Detalles Bibliográficos
Autores principales:	Nazish, Iqra, Mamais, Adamantios, Mallach, Anna, Bettencourt, Conceicao, Kaganovich, Alice, Warner, Tom, Hardy, John, Lewis, Patrick A., Pocock, Jennifer, Cookson, Mark R, Bandopadhyay, Rina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515904/ https://www.ncbi.nlm.nih.gov/pubmed/37745519 http://dx.doi.org/10.1101/2023.09.14.557532

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