A latent cardiomyocyte regeneration potential in human heart disease

Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective (14)C birth dating we analyzed cardiomyocyte renewal in p...

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Detalles Bibliográficos
Autores principales: Derks, Wouter, Rode, Julian, Collin, Sofia, Rost, Fabian, Heinke, Paula, Hariharan, Anjana, Pickel, Lauren, Simonova, Irina, Lázár, Enikő, Graham, Evan, Jashari, Ramadan, Andrä, Michaela, Jeppsson, Anders, Salehpour, Mehran, Alkass, Kanar, Druid, Henrik, Kyriakopoulos, Christos P., Taleb, Iosif, Shankar, Thirupura S., Selzman, Craig H., Sadek, Hesham, Jovinge, Stefan, Brusch, Lutz, Frisén, Jonas, Drakos, Stavros, Bergmann, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515906/
https://www.ncbi.nlm.nih.gov/pubmed/37745322
http://dx.doi.org/10.1101/2023.09.14.557681
Descripción
Sumario:Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective (14)C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18–50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.

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