A latent cardiomyocyte regeneration potential in human heart disease

Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective (14)C birth dating we analyzed cardiomyocyte renewal in p...

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Autores principales: Derks, Wouter, Rode, Julian, Collin, Sofia, Rost, Fabian, Heinke, Paula, Hariharan, Anjana, Pickel, Lauren, Simonova, Irina, Lázár, Enikő, Graham, Evan, Jashari, Ramadan, Andrä, Michaela, Jeppsson, Anders, Salehpour, Mehran, Alkass, Kanar, Druid, Henrik, Kyriakopoulos, Christos P., Taleb, Iosif, Shankar, Thirupura S., Selzman, Craig H., Sadek, Hesham, Jovinge, Stefan, Brusch, Lutz, Frisén, Jonas, Drakos, Stavros, Bergmann, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515906/
https://www.ncbi.nlm.nih.gov/pubmed/37745322
http://dx.doi.org/10.1101/2023.09.14.557681
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author Derks, Wouter
Rode, Julian
Collin, Sofia
Rost, Fabian
Heinke, Paula
Hariharan, Anjana
Pickel, Lauren
Simonova, Irina
Lázár, Enikő
Graham, Evan
Jashari, Ramadan
Andrä, Michaela
Jeppsson, Anders
Salehpour, Mehran
Alkass, Kanar
Druid, Henrik
Kyriakopoulos, Christos P.
Taleb, Iosif
Shankar, Thirupura S.
Selzman, Craig H.
Sadek, Hesham
Jovinge, Stefan
Brusch, Lutz
Frisén, Jonas
Drakos, Stavros
Bergmann, Olaf
author_facet Derks, Wouter
Rode, Julian
Collin, Sofia
Rost, Fabian
Heinke, Paula
Hariharan, Anjana
Pickel, Lauren
Simonova, Irina
Lázár, Enikő
Graham, Evan
Jashari, Ramadan
Andrä, Michaela
Jeppsson, Anders
Salehpour, Mehran
Alkass, Kanar
Druid, Henrik
Kyriakopoulos, Christos P.
Taleb, Iosif
Shankar, Thirupura S.
Selzman, Craig H.
Sadek, Hesham
Jovinge, Stefan
Brusch, Lutz
Frisén, Jonas
Drakos, Stavros
Bergmann, Olaf
author_sort Derks, Wouter
collection PubMed
description Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective (14)C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18–50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.
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spelling pubmed-105159062023-09-23 A latent cardiomyocyte regeneration potential in human heart disease Derks, Wouter Rode, Julian Collin, Sofia Rost, Fabian Heinke, Paula Hariharan, Anjana Pickel, Lauren Simonova, Irina Lázár, Enikő Graham, Evan Jashari, Ramadan Andrä, Michaela Jeppsson, Anders Salehpour, Mehran Alkass, Kanar Druid, Henrik Kyriakopoulos, Christos P. Taleb, Iosif Shankar, Thirupura S. Selzman, Craig H. Sadek, Hesham Jovinge, Stefan Brusch, Lutz Frisén, Jonas Drakos, Stavros Bergmann, Olaf bioRxiv Article Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective (14)C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18–50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically. Cold Spring Harbor Laboratory 2023-09-17 /pmc/articles/PMC10515906/ /pubmed/37745322 http://dx.doi.org/10.1101/2023.09.14.557681 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Derks, Wouter
Rode, Julian
Collin, Sofia
Rost, Fabian
Heinke, Paula
Hariharan, Anjana
Pickel, Lauren
Simonova, Irina
Lázár, Enikő
Graham, Evan
Jashari, Ramadan
Andrä, Michaela
Jeppsson, Anders
Salehpour, Mehran
Alkass, Kanar
Druid, Henrik
Kyriakopoulos, Christos P.
Taleb, Iosif
Shankar, Thirupura S.
Selzman, Craig H.
Sadek, Hesham
Jovinge, Stefan
Brusch, Lutz
Frisén, Jonas
Drakos, Stavros
Bergmann, Olaf
A latent cardiomyocyte regeneration potential in human heart disease
title A latent cardiomyocyte regeneration potential in human heart disease
title_full A latent cardiomyocyte regeneration potential in human heart disease
title_fullStr A latent cardiomyocyte regeneration potential in human heart disease
title_full_unstemmed A latent cardiomyocyte regeneration potential in human heart disease
title_short A latent cardiomyocyte regeneration potential in human heart disease
title_sort latent cardiomyocyte regeneration potential in human heart disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515906/
https://www.ncbi.nlm.nih.gov/pubmed/37745322
http://dx.doi.org/10.1101/2023.09.14.557681
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