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Diverse signatures of convergent evolution in cacti-associated yeasts
Many distantly related organisms have convergently evolved traits and lifestyles that enable them to live in similar ecological environments. However, the extent of phenotypic convergence evolving through the same or distinct genetic trajectories remains an open question. Here, we leverage a compreh...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515907/ https://www.ncbi.nlm.nih.gov/pubmed/37745407 http://dx.doi.org/10.1101/2023.09.14.557833 |
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author | Gonçalves, Carla Harrison, Marie-Claire Steenwyk, Jacob L. Opulente, Dana A. LaBella, Abigail L. Wolters, John F. Zhou, Xiaofan Shen, Xing-Xing Groenewald, Marizeth Hittinger, Chris Todd Rokas, Antonis |
author_facet | Gonçalves, Carla Harrison, Marie-Claire Steenwyk, Jacob L. Opulente, Dana A. LaBella, Abigail L. Wolters, John F. Zhou, Xiaofan Shen, Xing-Xing Groenewald, Marizeth Hittinger, Chris Todd Rokas, Antonis |
author_sort | Gonçalves, Carla |
collection | PubMed |
description | Many distantly related organisms have convergently evolved traits and lifestyles that enable them to live in similar ecological environments. However, the extent of phenotypic convergence evolving through the same or distinct genetic trajectories remains an open question. Here, we leverage a comprehensive dataset of genomic and phenotypic data from 1,049 yeast species in the subphylum Saccharomycotina (Kingdom Fungi, Phylum Ascomycota) to explore signatures of convergent evolution in cactophilic yeasts, ecological specialists associated with cacti. We inferred that the ecological association of yeasts with cacti arose independently ~17 times. Using machine-learning, we further found that cactophily can be predicted with 76% accuracy from functional genomic and phenotypic data. The most informative feature for predicting cactophily was thermotolerance, which is likely associated with duplication and altered evolutionary rates of genes impacting the cell envelope in several cactophilic lineages. We also identified horizontal gene transfer and duplication events of plant cell wall-degrading enzymes in distantly related cactophilic clades, suggesting that putatively adaptive traits evolved through disparate molecular mechanisms. Remarkably, multiple cactophilic lineages and their close relatives are emerging human opportunistic pathogens, suggesting that the cactophilic lifestyle—and perhaps more generally lifestyles favoring thermotolerance—may preadapt yeasts to cause human disease. This work underscores the potential of a multifaceted approach involving high throughput genomic and phenotypic data to shed light onto ecological adaptation and highlights how convergent evolution to wild environments could facilitate the transition to human pathogenicity. |
format | Online Article Text |
id | pubmed-10515907 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105159072023-09-23 Diverse signatures of convergent evolution in cacti-associated yeasts Gonçalves, Carla Harrison, Marie-Claire Steenwyk, Jacob L. Opulente, Dana A. LaBella, Abigail L. Wolters, John F. Zhou, Xiaofan Shen, Xing-Xing Groenewald, Marizeth Hittinger, Chris Todd Rokas, Antonis bioRxiv Article Many distantly related organisms have convergently evolved traits and lifestyles that enable them to live in similar ecological environments. However, the extent of phenotypic convergence evolving through the same or distinct genetic trajectories remains an open question. Here, we leverage a comprehensive dataset of genomic and phenotypic data from 1,049 yeast species in the subphylum Saccharomycotina (Kingdom Fungi, Phylum Ascomycota) to explore signatures of convergent evolution in cactophilic yeasts, ecological specialists associated with cacti. We inferred that the ecological association of yeasts with cacti arose independently ~17 times. Using machine-learning, we further found that cactophily can be predicted with 76% accuracy from functional genomic and phenotypic data. The most informative feature for predicting cactophily was thermotolerance, which is likely associated with duplication and altered evolutionary rates of genes impacting the cell envelope in several cactophilic lineages. We also identified horizontal gene transfer and duplication events of plant cell wall-degrading enzymes in distantly related cactophilic clades, suggesting that putatively adaptive traits evolved through disparate molecular mechanisms. Remarkably, multiple cactophilic lineages and their close relatives are emerging human opportunistic pathogens, suggesting that the cactophilic lifestyle—and perhaps more generally lifestyles favoring thermotolerance—may preadapt yeasts to cause human disease. This work underscores the potential of a multifaceted approach involving high throughput genomic and phenotypic data to shed light onto ecological adaptation and highlights how convergent evolution to wild environments could facilitate the transition to human pathogenicity. Cold Spring Harbor Laboratory 2023-09-17 /pmc/articles/PMC10515907/ /pubmed/37745407 http://dx.doi.org/10.1101/2023.09.14.557833 Text en https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Gonçalves, Carla Harrison, Marie-Claire Steenwyk, Jacob L. Opulente, Dana A. LaBella, Abigail L. Wolters, John F. Zhou, Xiaofan Shen, Xing-Xing Groenewald, Marizeth Hittinger, Chris Todd Rokas, Antonis Diverse signatures of convergent evolution in cacti-associated yeasts |
title | Diverse signatures of convergent evolution in cacti-associated yeasts |
title_full | Diverse signatures of convergent evolution in cacti-associated yeasts |
title_fullStr | Diverse signatures of convergent evolution in cacti-associated yeasts |
title_full_unstemmed | Diverse signatures of convergent evolution in cacti-associated yeasts |
title_short | Diverse signatures of convergent evolution in cacti-associated yeasts |
title_sort | diverse signatures of convergent evolution in cacti-associated yeasts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515907/ https://www.ncbi.nlm.nih.gov/pubmed/37745407 http://dx.doi.org/10.1101/2023.09.14.557833 |
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