Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

Nuclear speckles are membrane-less bodies within the cell nucleus enriched in RNA biogenesis, processing, and export factors. In this study we investigated speckle phenotype variation in human cancer, finding a reproducible speckle signature, based on RNA expression of speckle-resident proteins, acr...

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Detalles Bibliográficos
Autores principales: Alexander, Katherine A., Yu, Ruofan, Skuli, Nicolas, Coffey, Nathan J., Nguyen, Son, Faunce, Christine, Huang, Hua, Dardani, Ian P., Good, Austin L., Lim, Joan, Li, Catherine, Biddle, Nicholas, Joyce, Eric F., Raj, Arjun, Lee, Daniel, Keith, Brian, Simon, M. Celeste, Berger, Shelley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515914/
https://www.ncbi.nlm.nih.gov/pubmed/37745397
http://dx.doi.org/10.1101/2023.09.14.557228

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