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Decoding DNA sequence-driven evolution of the human brain epigenome at cellular resolution
DNA-based evolutionary comparisons of regulatory genomic elements enable insight into functional changes, overcoming tissue inaccessibility. Here, we harnessed adult and fetal cortex single-cell ATAC-seq datasets to uncover DNA substitutions specific to the human and human-ancestral lineages within...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515917/ https://www.ncbi.nlm.nih.gov/pubmed/37745404 http://dx.doi.org/10.1101/2023.09.14.557820 |