Linking Gba1 E326K mutation to microglia activation and mild age-dependent dopaminergic Neurodegeneration

Mutations in the GBA1 gene have been identified as a prevalent genetic risk factor for Parkinson’s disease (PD). GBA1 mutations impair enzymatic activity, leading to lysosomal dysfunction and elevated levels of α-synuclein (α-syn). While most research has primarily focused on GBA1’s role in promotin...

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Detalles Bibliográficos
Autores principales: Kweon, Sin Ho, Ryu, Hye Guk, Park, Hyeonwoo, Lee, Saebom, Kim, Namshik, Kwon, Seung-Hwan, Ma, Shi-Xun, Kim, Sangjune, Ko, Han Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515932/
https://www.ncbi.nlm.nih.gov/pubmed/37745332
http://dx.doi.org/10.1101/2023.09.14.557673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515932/
https://www.ncbi.nlm.nih.gov/pubmed/37745332
http://dx.doi.org/10.1101/2023.09.14.557673

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