Structural and dynamic changes in P-Rex1 upon activation by PIP(3) and inhibition by IP(4)

PIP(3)-dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a guanine nucleotide exchange factor (GEF) for Rac. The enzyme is synergistically activated by PIP(3) and the heterotrimeric Gβγ subunits, but me...

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Detalles Bibliográficos
Autores principales: Ravala, Sandeep K., Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A., Gutkind, J. Silvio, Cash, Jennifer N., Tesmer, John J. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10515948/
https://www.ncbi.nlm.nih.gov/pubmed/37745379
http://dx.doi.org/10.1101/2023.09.15.557836

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