Enhanced production of eicosanoids in plasma and activation of DNA damage pathways in PBMCs are correlated with the severity of ancestral COVID-19 infection

BACKGROUND: Many questions remain unanswered regarding the implication of lipid metabolites in severe SARS-CoV-2 infections. By re-analyzed sequencing data from the nasopharynx of a previously published cohort, we found that alox genes, involved in eicosanoid synthesis, were up-regulated in high WHO...

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Detalles Bibliográficos
Autores principales: Tomalka, Jeffrey A., Owings, Anna, Galeas-Pena, Michelle, Ziegler, Carly G.K., Robinson, Tanya O., Wichman, Thomas G., Laird, Hannah, Williams, Haley B., Dhaliwal, Neha S., Everman, Steven, Zafar, Yousaf, Shalek, Alex K., Horwitz, Bruce H., Ordovas-Montanes, Jose, Glover, Sarah C., Gibert, Yann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516085/
https://www.ncbi.nlm.nih.gov/pubmed/37745424
http://dx.doi.org/10.1101/2023.09.14.23295549

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