Structure-based design of a single-chain triple-disulfide-stabilized fusion-glycoprotein trimer that elicits high-titer neutralizing responses against human metapneumovirus

The Pneumoviridae family of viruses includes human metapneumovirus (HMPV) and respiratory syncytial virus (RSV). The closely related Paramyxoviridae family includes parainfluenza viruses (PIVs). These three viral pathogens cause acute respiratory tract infections with substantial disease burden in t...

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Detalles Bibliográficos
Autores principales: Ou, Li, Chen, Steven J., Teng, I-Ting, Yang, Lijuan, Zhang, Baoshan, Zhou, Tongqing, Biju, Andrea, Cheng, Cheng, Kong, Wing-Pui, Morano, Nicholas C., Stancofski, Erik-Stephane D., Todd, John-Paul, Tsybovsky, Yaroslav, Wang, Shuishu, Zheng, Cheng-Yan, Mascola, John R., Shapiro, Lawrence, Woodward, Ruth A., Buchholz, Ursula J., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516418/
https://www.ncbi.nlm.nih.gov/pubmed/37738240
http://dx.doi.org/10.1371/journal.ppat.1011584

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