Cargando…

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy...

Descripción completa

Detalles Bibliográficos
Autores principales: Baldeon Vaca, Gabriela, Meyer, Michelle, Cadete, Ana, Hsiao, Chiaowen Joyce, Golding, Anne, Jeon, Albert, Jacquinet, Eric, Azcue, Emily, Guan, Chenxia Monica, Sanchez-Felix, Xavier, Pietzsch, Colette A., Mire, Chad E., Hyde, Matthew A., Comeaux, Margaret E., Williams, Julie M., Sung, Jean C., Carfi, Andrea, Edwards, Darin K., Bukreyev, Alexander, Bahl, Kapil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/
https://www.ncbi.nlm.nih.gov/pubmed/37738334
http://dx.doi.org/10.1126/sciadv.adh1655
Descripción
Sumario:Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine.