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Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy...

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Autores principales: Baldeon Vaca, Gabriela, Meyer, Michelle, Cadete, Ana, Hsiao, Chiaowen Joyce, Golding, Anne, Jeon, Albert, Jacquinet, Eric, Azcue, Emily, Guan, Chenxia Monica, Sanchez-Felix, Xavier, Pietzsch, Colette A., Mire, Chad E., Hyde, Matthew A., Comeaux, Margaret E., Williams, Julie M., Sung, Jean C., Carfi, Andrea, Edwards, Darin K., Bukreyev, Alexander, Bahl, Kapil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/
https://www.ncbi.nlm.nih.gov/pubmed/37738334
http://dx.doi.org/10.1126/sciadv.adh1655
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author Baldeon Vaca, Gabriela
Meyer, Michelle
Cadete, Ana
Hsiao, Chiaowen Joyce
Golding, Anne
Jeon, Albert
Jacquinet, Eric
Azcue, Emily
Guan, Chenxia Monica
Sanchez-Felix, Xavier
Pietzsch, Colette A.
Mire, Chad E.
Hyde, Matthew A.
Comeaux, Margaret E.
Williams, Julie M.
Sung, Jean C.
Carfi, Andrea
Edwards, Darin K.
Bukreyev, Alexander
Bahl, Kapil
author_facet Baldeon Vaca, Gabriela
Meyer, Michelle
Cadete, Ana
Hsiao, Chiaowen Joyce
Golding, Anne
Jeon, Albert
Jacquinet, Eric
Azcue, Emily
Guan, Chenxia Monica
Sanchez-Felix, Xavier
Pietzsch, Colette A.
Mire, Chad E.
Hyde, Matthew A.
Comeaux, Margaret E.
Williams, Julie M.
Sung, Jean C.
Carfi, Andrea
Edwards, Darin K.
Bukreyev, Alexander
Bahl, Kapil
author_sort Baldeon Vaca, Gabriela
collection PubMed
description Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine.
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spelling pubmed-105164942023-09-23 Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection Baldeon Vaca, Gabriela Meyer, Michelle Cadete, Ana Hsiao, Chiaowen Joyce Golding, Anne Jeon, Albert Jacquinet, Eric Azcue, Emily Guan, Chenxia Monica Sanchez-Felix, Xavier Pietzsch, Colette A. Mire, Chad E. Hyde, Matthew A. Comeaux, Margaret E. Williams, Julie M. Sung, Jean C. Carfi, Andrea Edwards, Darin K. Bukreyev, Alexander Bahl, Kapil Sci Adv Biomedicine and Life Sciences Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine. American Association for the Advancement of Science 2023-09-22 /pmc/articles/PMC10516494/ /pubmed/37738334 http://dx.doi.org/10.1126/sciadv.adh1655 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Baldeon Vaca, Gabriela
Meyer, Michelle
Cadete, Ana
Hsiao, Chiaowen Joyce
Golding, Anne
Jeon, Albert
Jacquinet, Eric
Azcue, Emily
Guan, Chenxia Monica
Sanchez-Felix, Xavier
Pietzsch, Colette A.
Mire, Chad E.
Hyde, Matthew A.
Comeaux, Margaret E.
Williams, Julie M.
Sung, Jean C.
Carfi, Andrea
Edwards, Darin K.
Bukreyev, Alexander
Bahl, Kapil
Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title_full Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title_fullStr Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title_full_unstemmed Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title_short Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
title_sort intranasal mrna-lnp vaccination protects hamsters from sars-cov-2 infection
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/
https://www.ncbi.nlm.nih.gov/pubmed/37738334
http://dx.doi.org/10.1126/sciadv.adh1655
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