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Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection
Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/ https://www.ncbi.nlm.nih.gov/pubmed/37738334 http://dx.doi.org/10.1126/sciadv.adh1655 |
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author | Baldeon Vaca, Gabriela Meyer, Michelle Cadete, Ana Hsiao, Chiaowen Joyce Golding, Anne Jeon, Albert Jacquinet, Eric Azcue, Emily Guan, Chenxia Monica Sanchez-Felix, Xavier Pietzsch, Colette A. Mire, Chad E. Hyde, Matthew A. Comeaux, Margaret E. Williams, Julie M. Sung, Jean C. Carfi, Andrea Edwards, Darin K. Bukreyev, Alexander Bahl, Kapil |
author_facet | Baldeon Vaca, Gabriela Meyer, Michelle Cadete, Ana Hsiao, Chiaowen Joyce Golding, Anne Jeon, Albert Jacquinet, Eric Azcue, Emily Guan, Chenxia Monica Sanchez-Felix, Xavier Pietzsch, Colette A. Mire, Chad E. Hyde, Matthew A. Comeaux, Margaret E. Williams, Julie M. Sung, Jean C. Carfi, Andrea Edwards, Darin K. Bukreyev, Alexander Bahl, Kapil |
author_sort | Baldeon Vaca, Gabriela |
collection | PubMed |
description | Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine. |
format | Online Article Text |
id | pubmed-10516494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105164942023-09-23 Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection Baldeon Vaca, Gabriela Meyer, Michelle Cadete, Ana Hsiao, Chiaowen Joyce Golding, Anne Jeon, Albert Jacquinet, Eric Azcue, Emily Guan, Chenxia Monica Sanchez-Felix, Xavier Pietzsch, Colette A. Mire, Chad E. Hyde, Matthew A. Comeaux, Margaret E. Williams, Julie M. Sung, Jean C. Carfi, Andrea Edwards, Darin K. Bukreyev, Alexander Bahl, Kapil Sci Adv Biomedicine and Life Sciences Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy of intranasally administered messenger RNA (mRNA)–lipid nanoparticle (LNP) encapsulated vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Syrian golden hamsters. Intranasal mRNA-LNP vaccination systemically induced spike-specific binding [immunoglobulin G (IgG) and IgA] and neutralizing antibodies. Intranasally vaccinated hamsters also had decreased viral loads in the respiratory tract, reduced lung pathology, and prevented weight loss after SARS-CoV-2 challenge. Together, this study demonstrates successful immunogenicity and protection against respiratory viral infection by an intranasally administered mRNA-LNP vaccine. American Association for the Advancement of Science 2023-09-22 /pmc/articles/PMC10516494/ /pubmed/37738334 http://dx.doi.org/10.1126/sciadv.adh1655 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Baldeon Vaca, Gabriela Meyer, Michelle Cadete, Ana Hsiao, Chiaowen Joyce Golding, Anne Jeon, Albert Jacquinet, Eric Azcue, Emily Guan, Chenxia Monica Sanchez-Felix, Xavier Pietzsch, Colette A. Mire, Chad E. Hyde, Matthew A. Comeaux, Margaret E. Williams, Julie M. Sung, Jean C. Carfi, Andrea Edwards, Darin K. Bukreyev, Alexander Bahl, Kapil Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title | Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title_full | Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title_fullStr | Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title_full_unstemmed | Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title_short | Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection |
title_sort | intranasal mrna-lnp vaccination protects hamsters from sars-cov-2 infection |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/ https://www.ncbi.nlm.nih.gov/pubmed/37738334 http://dx.doi.org/10.1126/sciadv.adh1655 |
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