Cargando…

Intranasal mRNA-LNP vaccination protects hamsters from SARS-CoV-2 infection

Intranasal vaccination represents a promising approach for preventing disease caused by respiratory pathogens by eliciting a mucosal immune response in the respiratory tract that may act as an early barrier to infection and transmission. This study investigated immunogenicity and protective efficacy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baldeon Vaca, Gabriela, Meyer, Michelle, Cadete, Ana, Hsiao, Chiaowen Joyce, Golding, Anne, Jeon, Albert, Jacquinet, Eric, Azcue, Emily, Guan, Chenxia Monica, Sanchez-Felix, Xavier, Pietzsch, Colette A., Mire, Chad E., Hyde, Matthew A., Comeaux, Margaret E., Williams, Julie M., Sung, Jean C., Carfi, Andrea, Edwards, Darin K., Bukreyev, Alexander, Bahl, Kapil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516494/ https://www.ncbi.nlm.nih.gov/pubmed/37738334 http://dx.doi.org/10.1126/sciadv.adh1655

Ejemplares similares

A single-dose F1-based mRNA-LNP vaccine provides protection against the lethal plague bacterium
por: Kon, Edo, et al.
Publicado: (2023)

A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2
por: Ilinykh, Philipp A., et al.
Publicado: (2022)

Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery
por: Das, Riddha, et al.
Publicado: (2023)

A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
por: Malherbe, Delphine C., et al.
Publicado: (2021)

Intranasal parainfluenza virus type 5 (PIV5)–vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study
por: Spearman, Paul, et al.
Publicado: (2023)

The effects of PEGylation on LNP based mRNA delivery to the eye
por: Ryals, Renee C., et al.
Publicado: (2020)

Allergic Reactions and Anaphylaxis to LNP-Based COVID-19 Vaccines
por: Moghimi, S. Moein
Publicado: (2021)

Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus
por: Safronetz, David, et al.
Publicado: (2011)

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases
por: Pan, Xin, et al.
Publicado: (2010)

Distributions of HLA-A and -B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations
por: Zhu, Bo-feng, et al.
Publicado: (2010)

Sporadic Creutzfeldt–Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling
por: Gawinecka, Joanna, et al.
Publicado: (2012)

Surface modifications of influenza proteins upon virus inactivation by β-propiolactone*
por: She, Yi-Min, et al.
Publicado: (2013)

Applications of mass spectrometry for quantitative protein analysis in formalin-fixed paraffin-embedded tissues
por: Steiner, Carine, et al.
Publicado: (2014)

MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis
por: Winter, Martin, et al.
Publicado: (2017)

Binodal, wireless epidermal electronic systems with in-sensor analytics for neonatal intensive care
por: Chung, Ha Uk, et al.
Publicado: (2019)

Proteomics insights into DNA damage response and translating this knowledge to clinical strategies
por: von Stechow, Louise, et al.
Publicado: (2016)

Proteomic characterization of microdissected breast tissue environment provides a protein‐level overview of malignant transformation
por: Braakman, René B. H., et al.
Publicado: (2017)

Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice
por: Garcia-Dominguez, Dario, et al.
Publicado: (2022)

Non-Immunotherapy Application of LNP-mRNA: Maximizing Efficacy and Safety
por: Vlatkovic, Irena
Publicado: (2021)

Optimal self-assembly of lipid nanoparticles (LNP) in a ring micromixer
por: Ripoll, Manon, et al.
Publicado: (2022)

Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
por: Kiaie, Seyed Hossein, et al.
Publicado: (2022)

Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species
por: Peng, Lei, et al.
Publicado: (2022)

Therapeutic Potential of LNP-Mediated Delivery of miR-634 for Cancer Therapy
por: Gokita, Kentaro, et al.
Publicado: (2019)

Thermotropic effects of PEGylated lipids on the stability of HPPH-encapsulated lipid nanoparticles (LNP)
por: Kalyanram, Poornima, et al.
Publicado: (2021)

Sex differences in the incidence of anaphylaxis to LNP-mRNA COVID-19 vaccines
por: Somiya, Masaharu, et al.
Publicado: (2021)

Intranasal administration of convalescent plasma protects against SARS-CoV-2 infection in hamsters
por: Wouters, Elise, et al.
Publicado: (2023)

Systemic and mucosal immune profiling in asymptomatic and symptomatic SARS-CoV-2–infected individuals reveal unlinked immune signatures
por: Ravichandran, Supriya, et al.
Publicado: (2021)

Could amantadine interfere with COVID-19 vaccines based on the LNP-mRNA platform?
por: Fedorowski, Jaroslaw J.
Publicado: (2021)

Determination of significant immunological timescales from mRNA-LNP-based vaccines in humans
por: Moyles, Iain R., et al.
Publicado: (2023)

Astrocyte-targeted siRNA delivery by adenosine-functionalized LNP in mouse TBI model
por: Xiao, Hai, et al.
Publicado: (2023)

Volume-Associated Clinical and Histopathological Effects of Intranasal Instillation in Syrian Hamsters: Considerations for Infection and Therapeutic Studies
por: Forero, Catalina, et al.
Publicado: (2022)

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters
por: Liu, Shufeng, et al.
Publicado: (2022)

Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum
por: Casey, Amanda K., et al.
Publicado: (2015)

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
por: Maugeri, Marco, et al.
Publicado: (2019)

Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum
por: Hirano, Yasuhiro, et al.
Publicado: (2020)

Impact of Ribosome Activity on SARS-CoV-2 LNP – Based mRNA Vaccines
por: Tsiambas, Evangelos, et al.
Publicado: (2021)

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
por: Connors, Jennifer, et al.
Publicado: (2022)

Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals
por: Connors, Jennifer, et al.
Publicado: (2023)

Ionizable Lipids with Triazole Moiety from Click Reaction for LNP-Based mRNA Delivery
por: Wang, Yixiang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_67uhr74s4h869ealrhukgavl6e