Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington’s disease

Huntington’s disease is caused by a CAG repeat expansion in the Huntingtin gene (HTT), coding for polyglutamine in the Huntingtin protein, with longer CAG repeats causing earlier age of onset. The variable ‘Age’ × (‘CAG’—L), where ‘Age’ is the current age of the individual, ‘CAG’ is the repeat lengt...

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Detalles Bibliográficos
Autores principales: Liu, Chin-Fu, Younes, Laurent, Tong, Xiao J, Hinkle, Jared T, Wang, Maggie, Phatak, Sanika, Xu, Xin, Bu, Xuan, Looi, Vivian, Bang, Jee, Tabrizi, Sarah J, Scahill, Rachael I, Paulsen, Jane S, Georgiou-Karistianis, Nellie, Faria, Andreia V, Miller, Michael I, Ratnanather, J Tilak, Ross, Christopher A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516592/
https://www.ncbi.nlm.nih.gov/pubmed/37744022
http://dx.doi.org/10.1093/braincomms/fcad214

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