Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer

BACKGROUND: Genome integrity is essential for the survival of an organism. DNA mismatch repair (MMR) genes (e.g., MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA damage response pathway for genome integrity maintenance. Germline mutations of MMR genes can lead to Lynch syndrome or consti...

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Detalles Bibliográficos
Autores principales: Song, Yurong, Kerr, Travis D., Sanders, Chelsea, Dai, Lisheng, Baxter, Shaneen S., Somerville, Brandon, Baugher, Ryan N., Mellott, Stephanie D., Young, Todd B., Lawhorn, Heidi E., Plona, Teri M., Xu, Bingfang, Wei, Lei, Hu, Qiang, Liu, Song, Hutson, Alan, Karim, Baktiar, Burkett, Sandra, Difilippantonio, Simone, Pinto, Ligia, Gebert, Johannes, Kloor, Matthias, Lipkin, Steven M., Sei, Shizuko, Shoemaker, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516605/
https://www.ncbi.nlm.nih.gov/pubmed/37746286
http://dx.doi.org/10.3389/fonc.2023.1223915

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