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The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair

Histone deacetylase 6 (HDAC6) mediates DNA damage signaling by regulating the mismatch repair and nucleotide excision repair pathways. Whether HDAC6 also mediates DNA double-strand break (DSB) repair is unclear. Here, we report that HDAC6 negatively regulates DSB repair in an enzyme activity-indepen...

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Detalles Bibliográficos
Autores principales:	Qiu, Lingyu, Xu, Wenchao, Lu, Xiaopeng, Chen, Feng, Chen, Yongcan, Tian, Yuan, Zhu, Qian, Liu, Xiangyu, Wang, Yongqing, Pei, Xin-Hai, Xu, Xingzhi, Zhang, Jun, Zhu, Wei-Guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516627/ https://www.ncbi.nlm.nih.gov/pubmed/37503842 http://dx.doi.org/10.1093/nar/gkad631

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