FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability

FANCD2 protein, a key coordinator and effector of the interstrand crosslink repair pathway, is also required to prevent excessive nascent strand degradation at hydroxyurea-induced stalled forks. The RAD51 recombinase has also been implicated in regulation of resection at stalled replication forks. T...

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Detalles Bibliográficos
Autores principales: Liu, Wenpeng, Polaczek, Piotr, Roubal, Ivan, Meng, Yuan, Choe, Won-chae, Caron, Marie-Christine, Sedgeman, Carl A, Xi, Yu, Liu, Changwei, Wu, Qiong, Zheng, Li, Masson, Jean-Yves, Shen, Binghui, Campbell, Judith L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516637/
https://www.ncbi.nlm.nih.gov/pubmed/37526271
http://dx.doi.org/10.1093/nar/gkad624

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