INHAT subunit SET/TAF-Iβ regulates PRC1-independent H2AK119 mono-ubiquitination via E3 ligase MIB1 in colon cancer

SET/TAF-Iβ, a subunit of the inhibitor of acetyltransferases (INHAT) complex, exhibits transcriptional repression activity by inhibiting histone acetylation. We find that SET/TAF-Iβ regulates mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub), which is involved in polycomb-mediated transcr...

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Detalles Bibliográficos
Autores principales: Park, Junyoung, Kim, Ji-Young, Park, Jin Woo, Kang, Joo Young, Oh, Hyein, Hahm, Ja Young, Chae, Yun-Cheol, Chakravarti, Debabrata, Seo, Sang Beom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Cancer Gene Regulation, Chromatin, and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516711/
https://www.ncbi.nlm.nih.gov/pubmed/37746636
http://dx.doi.org/10.1093/narcan/zcad050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516711/
https://www.ncbi.nlm.nih.gov/pubmed/37746636
http://dx.doi.org/10.1093/narcan/zcad050

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