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Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study
A neutron beam for boron neutron capture therapy (BNCT) of deep-seated tumours is designed to maintain a high flux of epithermal neutrons, while keeping the thermal and fast neutron component as low as possible. These neutrons (thermal and fast) have a high relative biological effectiveness in compa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516737/ https://www.ncbi.nlm.nih.gov/pubmed/37607589 http://dx.doi.org/10.1093/jrr/rrad056 |
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author | Hu, Naonori Suzuki, Minoru Masunaga, Shin-ichiro Kashino, Genro Kinashi, Yuko Chen, Yi-Wen Liu, Yong Uehara, Koki Mitsumoto, Toshinori Tanaka, Hiroki Ono, Koji |
author_facet | Hu, Naonori Suzuki, Minoru Masunaga, Shin-ichiro Kashino, Genro Kinashi, Yuko Chen, Yi-Wen Liu, Yong Uehara, Koki Mitsumoto, Toshinori Tanaka, Hiroki Ono, Koji |
author_sort | Hu, Naonori |
collection | PubMed |
description | A neutron beam for boron neutron capture therapy (BNCT) of deep-seated tumours is designed to maintain a high flux of epithermal neutrons, while keeping the thermal and fast neutron component as low as possible. These neutrons (thermal and fast) have a high relative biological effectiveness in comparison with high energy photon beams used for conventional X-ray radiotherapy. In the past, neutrons for the purpose of BNCT were generated using nuclear reactors. However, there are various challenges that arise when installing a reactor in a hospital environment. From 2006, the Kyoto University Research Reactor Institute, in collaboration with Sumitomo Heavy Industries, began the development of an accelerator-based neutron source for clinical BNCT in a bid to overcome the shortcomings of a nuclear reactor-based neutron source. Following installation and beam performance testing, in vitro studies were performed to assess the biological effect of the neutron beam. Four different cell lines were prepared and irradiated using the accelerator-based neutron source. Following neutron and gamma ray irradiation, the survival curve for each cell line was calculated. The biological end point to determine the relative biological effectiveness (RBE) was set to 10% cell survival, and the D(10) for each cell line was determined. The RBE of the accelerator-based neutron beam was evaluated to be 2.62. |
format | Online Article Text |
id | pubmed-10516737 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105167372023-09-24 Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study Hu, Naonori Suzuki, Minoru Masunaga, Shin-ichiro Kashino, Genro Kinashi, Yuko Chen, Yi-Wen Liu, Yong Uehara, Koki Mitsumoto, Toshinori Tanaka, Hiroki Ono, Koji J Radiat Res Regular paper A neutron beam for boron neutron capture therapy (BNCT) of deep-seated tumours is designed to maintain a high flux of epithermal neutrons, while keeping the thermal and fast neutron component as low as possible. These neutrons (thermal and fast) have a high relative biological effectiveness in comparison with high energy photon beams used for conventional X-ray radiotherapy. In the past, neutrons for the purpose of BNCT were generated using nuclear reactors. However, there are various challenges that arise when installing a reactor in a hospital environment. From 2006, the Kyoto University Research Reactor Institute, in collaboration with Sumitomo Heavy Industries, began the development of an accelerator-based neutron source for clinical BNCT in a bid to overcome the shortcomings of a nuclear reactor-based neutron source. Following installation and beam performance testing, in vitro studies were performed to assess the biological effect of the neutron beam. Four different cell lines were prepared and irradiated using the accelerator-based neutron source. Following neutron and gamma ray irradiation, the survival curve for each cell line was calculated. The biological end point to determine the relative biological effectiveness (RBE) was set to 10% cell survival, and the D(10) for each cell line was determined. The RBE of the accelerator-based neutron beam was evaluated to be 2.62. Oxford University Press 2023-08-22 /pmc/articles/PMC10516737/ /pubmed/37607589 http://dx.doi.org/10.1093/jrr/rrad056 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Regular paper Hu, Naonori Suzuki, Minoru Masunaga, Shin-ichiro Kashino, Genro Kinashi, Yuko Chen, Yi-Wen Liu, Yong Uehara, Koki Mitsumoto, Toshinori Tanaka, Hiroki Ono, Koji Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title | Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title_full | Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title_fullStr | Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title_full_unstemmed | Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title_short | Experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical BNCT: in vitro study |
title_sort | experimentally determined relative biological effectiveness of cyclotron-based epithermal neutrons designed for clinical bnct: in vitro study |
topic | Regular paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516737/ https://www.ncbi.nlm.nih.gov/pubmed/37607589 http://dx.doi.org/10.1093/jrr/rrad056 |
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