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Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance

Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower ext...

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Autores principales: Jaatela, Julia, Nurmi, Timo, Vallinoja, Jaakko, Mäenpää, Helena, Sairanen, Viljami, Piitulainen, Harri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516810/
https://www.ncbi.nlm.nih.gov/pubmed/37615759
http://dx.doi.org/10.1007/s00429-023-02692-1
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author Jaatela, Julia
Nurmi, Timo
Vallinoja, Jaakko
Mäenpää, Helena
Sairanen, Viljami
Piitulainen, Harri
author_facet Jaatela, Julia
Nurmi, Timo
Vallinoja, Jaakko
Mäenpää, Helena
Sairanen, Viljami
Piitulainen, Harri
author_sort Jaatela, Julia
collection PubMed
description Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifically gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n = 18) or diplegic (n = 13) CP and in their age-matched controls (n = 34). The modern diffusion-weighted MRI analysis included the diffusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean diffusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The diffusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP offering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specificity of clinical diagnosis and targeted rehabilitation in CP. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-023-02692-1.
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spelling pubmed-105168102023-09-24 Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance Jaatela, Julia Nurmi, Timo Vallinoja, Jaakko Mäenpää, Helena Sairanen, Viljami Piitulainen, Harri Brain Struct Funct Original Article Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifically gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n = 18) or diplegic (n = 13) CP and in their age-matched controls (n = 34). The modern diffusion-weighted MRI analysis included the diffusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean diffusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The diffusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP offering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specificity of clinical diagnosis and targeted rehabilitation in CP. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00429-023-02692-1. Springer Berlin Heidelberg 2023-08-24 2023 /pmc/articles/PMC10516810/ /pubmed/37615759 http://dx.doi.org/10.1007/s00429-023-02692-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Jaatela, Julia
Nurmi, Timo
Vallinoja, Jaakko
Mäenpää, Helena
Sairanen, Viljami
Piitulainen, Harri
Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title_full Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title_fullStr Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title_full_unstemmed Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title_short Altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
title_sort altered corpus callosum structure in adolescents with cerebral palsy: connection to gait and balance
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516810/
https://www.ncbi.nlm.nih.gov/pubmed/37615759
http://dx.doi.org/10.1007/s00429-023-02692-1
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