Quantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering

We present a generically applicable approach to determine an extensive set of size-dependent critical quality attributes inside nanoparticulate pharmaceutical products. By coupling asymmetrical-flow field-flow fractionation (AF4) measurements directly in-line with solution small angle X-ray scatteri...

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Detalles Bibliográficos
Autores principales: Graewert, Melissa A., Wilhelmy, Christoph, Bacic, Tijana, Schumacher, Jens, Blanchet, Clement, Meier, Florian, Drexel, Roland, Welz, Roland, Kolb, Bastian, Bartels, Kim, Nawroth, Thomas, Klein, Thorsten, Svergun, Dmitri, Langguth, Peter, Haas, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516866/
https://www.ncbi.nlm.nih.gov/pubmed/37737457
http://dx.doi.org/10.1038/s41598-023-42274-z

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