Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas

Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonstrate that TMZ-derived 5-aminoimidazole-4-carboxamide (AICA) is converted to AICA ribosyl-5-...

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Detalles Bibliográficos
Autores principales: Yin, Jianxing, Wang, Xiefeng, Ge, Xin, Ding, Fangshu, Shi, Zhumei, Ge, Zehe, Huang, Guang, Zhao, Ningwei, Chen, Dongyin, Zhang, Junxia, Agnihotri, Sameer, Cao, Yuandong, Ji, Jing, Lin, Fan, Wang, Qianghu, Zhou, Qigang, Wang, Xiuxing, You, Yongping, Lu, Zhimin, Qian, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516874/
https://www.ncbi.nlm.nih.gov/pubmed/37737247
http://dx.doi.org/10.1038/s41467-023-41663-2

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