In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy

The prognosis of lung metastatic osteosarcoma (OS) remains disappointing. siRNA-based gene silencing of VEGFR2 is a promising treatment strategy for lung metastatic OS, but there is a lack of safe and efficient delivery systems to encapsulate siRNAs for in vivo administration. This study presented a...

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Detalles Bibliográficos
Autores principales: Yu, Lingfeng, Fan, Gentao, Wang, Qingyan, Zhu, Yan, Zhu, Hao, Chang, Jiang, Wang, Zhen, Zhan, Shoubin, Hua, Xianming, She, Diankun, Huang, Jianhao, Wang, Yicun, Zhao, Jianning, Zhang, Chen-Yu, Chen, Xi, Zhou, Guangxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516902/
https://www.ncbi.nlm.nih.gov/pubmed/37739958
http://dx.doi.org/10.1038/s41419-023-06159-3

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