Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G(s) signaling

Many orphan G protein-coupled receptors (GPCRs) remain understudied because their endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like orphan GPCRs including GPR61, GPR161 and GPR174 increase the cAMP level similarly to fully activated D1 dopamine receptor (D1R). We r...

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Detalles Bibliográficos
Autores principales: Nie, Yingying, Qiu, Zeming, Chen, Sijia, Chen, Zhao, Song, Xiaocui, Ma, Yan, Huang, Niu, Cyster, Jason G., Zheng, Sanduo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516915/
https://www.ncbi.nlm.nih.gov/pubmed/37737235
http://dx.doi.org/10.1038/s41467-023-41654-3

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