Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding

The ring-shaped cohesin complex is a key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated by ATP. This process is hindered by Smc3 acetylation. However, the molecular mechanism underlying this inh...

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Detalles Bibliográficos
Autores principales: Kaushik, Aditi, Than, Thane, Petela, Naomi J., Voulgaris, Menelaos, Percival, Charlotte, Daniels, Peter, Rafferty, John B., Nasmyth, Kim A., Hu, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516938/
https://www.ncbi.nlm.nih.gov/pubmed/37739959
http://dx.doi.org/10.1038/s41467-023-41596-w

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