Altered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model

Alzheimer’s disease (AD) is characterized by toxic protein accumulation in the brain. Ubiquitination is essential for protein clearance in cells, making altered ubiquitin signaling crucial in AD development. A defective variant, ubiquitin B + 1 (UBB(+1)), created by a non-hereditary RNA frameshift m...

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Detalles Bibliográficos
Autores principales: Maniv, Inbal, Sarji, Mahasen, Bdarneh, Anwar, Feldman, Alona, Ankawa, Roi, Koren, Elle, Magid-Gold, Inbar, Reis, Noa, Soteriou, Despina, Salomon-Zimri, Shiran, Lavy, Tali, Kesselman, Ellina, Koifman, Naama, Kurz, Thimo, Kleifeld, Oded, Michaelson, Daniel, van Leeuwen, Fred W., Verheijen, Bert M., Fuchs, Yaron, Glickman, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10516951/
https://www.ncbi.nlm.nih.gov/pubmed/37739965
http://dx.doi.org/10.1038/s41467-023-41545-7

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