Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

The arginine dependency of cancer cells creates metabolic vulnerability. In this study, we examine the impact of arginine availability on DNA replication and genotoxicity resistance. Using DNA combing assays, we find that limiting extracellular arginine results in the arrest of cancer cells at S pha...

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Detalles Bibliográficos
Autores principales: Wang, Yi-Chang, Kelso, Andrew A., Karamafrooz, Adak, Chen, Yi-Hsuan, Chen, Wei-Kai, Cheng, Chun-Ting, Qi, Yue, Gu, Long, Malkas, Linda, Taglialatela, Angelo, Kung, Hsing-Jien, Moldovan, George-Lucian, Ciccia, Alberto, Stark, Jeremy M., Ann, David K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517088/
https://www.ncbi.nlm.nih.gov/pubmed/36961817
http://dx.doi.org/10.1016/j.celrep.2023.112296

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