Breaking barriers for glioblastoma with a path to enhanced drug delivery

Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemot...

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Detalles Bibliográficos
Autores principales: Noorani, Imran, de la Rosa, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517119/
https://www.ncbi.nlm.nih.gov/pubmed/37737212
http://dx.doi.org/10.1038/s41467-023-41694-9
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author Noorani, Imran
de la Rosa, Jorge
author_facet Noorani, Imran
de la Rosa, Jorge
author_sort Noorani, Imran
collection PubMed
description Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques.
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spelling pubmed-105171192023-09-24 Breaking barriers for glioblastoma with a path to enhanced drug delivery Noorani, Imran de la Rosa, Jorge Nat Commun Comment Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB with nanoparticles boosts intratumoural chemotherapy concentration, prolonging survival. We discuss prospects for clinical translation of exemplary innovative techniques. Nature Publishing Group UK 2023-09-22 /pmc/articles/PMC10517119/ /pubmed/37737212 http://dx.doi.org/10.1038/s41467-023-41694-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Noorani, Imran
de la Rosa, Jorge
Breaking barriers for glioblastoma with a path to enhanced drug delivery
title Breaking barriers for glioblastoma with a path to enhanced drug delivery
title_full Breaking barriers for glioblastoma with a path to enhanced drug delivery
title_fullStr Breaking barriers for glioblastoma with a path to enhanced drug delivery
title_full_unstemmed Breaking barriers for glioblastoma with a path to enhanced drug delivery
title_short Breaking barriers for glioblastoma with a path to enhanced drug delivery
title_sort breaking barriers for glioblastoma with a path to enhanced drug delivery
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517119/
https://www.ncbi.nlm.nih.gov/pubmed/37737212
http://dx.doi.org/10.1038/s41467-023-41694-9
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