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Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis

Hepatocarcinogenesis is initiated by repeated hepatocyte death and liver damage, and the underlying mechanisms mediating cell death and the subsequent carcinogenesis remain to be fully investigated. Immunoresponsive gene 1 (IRG1) and its enzymatic metabolite itaconate are known to suppress inflammat...

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Detalles Bibliográficos
Autores principales:	Zhang, Liyuan, Dong, Yue, Zhang, Luxin, Wang, Minjun, Zhou, Ye, Jia, Kaiwei, Wang, Suyuan, Wang, Mu, Li, Yunhui, Luo, Shudan, Lu, Shan, Fan, Yiwen, Zhang, Dingji, Yang, Yingyun, Li, Nan, Yu, Yizhi, Cao, Xuetao, Hou, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517141/ https://www.ncbi.nlm.nih.gov/pubmed/37737207 http://dx.doi.org/10.1038/s41419-023-06155-7

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