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Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML

Dysregulation of innate immune signaling is a hallmark of hematologic malignancies. Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have focused on the kinase IRAK4. IRAK4 inhibitors have achieved promising, th...

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Detalles Bibliográficos
Autores principales:	Bennett, Joshua, Ishikawa, Chiharu, Agarwal, Puneet, Yeung, Jennifer, Sampson, Avery, Uible, Emma, Vick, Eric, Bolanos, Lyndsey C., Hueneman, Kathleen, Wunderlich, Mark, Kolt, Amal, Choi, Kwangmin, Volk, Andrew, Greis, Kenneth D., Rosenbaum, Jan, Hoyt, Scott B., Thomas, Craig J., Starczynowski, Daniel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Myeloid Neoplasia
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517216/ https://www.ncbi.nlm.nih.gov/pubmed/37172199 http://dx.doi.org/10.1182/blood.2022018718

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