Themis controls T cell activation, effector functions, and metabolism of peripheral CD8(+) T cells

Themis is important in regulating positive selection of thymocytes during T cell development, but its role in peripheral T cells is less understood. Here, we investigated T cell activation and its sequelae using a tamoxifen-mediated, acute Themis deletion mouse model. We find that proliferation, eff...

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Detalles Bibliográficos
Autores principales: Gautam, Namrata, Wojciech, Lukasz, Yap, Jiawei, Chua, Yen Leong, Ding, Eyan MW, Sim, Don CN, Tan, Alrina SM, Ahl, Patricia J, Prasad, Mukul, Tung, Desmond WH, Connolly, John E, Adriani, Giulia, Brzostek, Joanna, Gascoigne, Nicholas RJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517225/
https://www.ncbi.nlm.nih.gov/pubmed/37739454
http://dx.doi.org/10.26508/lsa.202302156

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