Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism

Uric acid is the main means of nitrogen excretion in uricotelic vertebrates (birds and reptiles) and the end product of purine catabolism in humans and a few other mammals. While uricase is inactivated in mammals unable to degrade urate, the presence of orthologous genes without inactivating mutatio...

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Detalles Bibliográficos
Autores principales: Mori, Giulia, Liuzzi, Anastasia, Ronda, Luca, Di Palma, Michele, Chegkazi, Magda S, Bui, Soi, Garcia-Maya, Mitla, Ragazzini, Jasmine, Malatesta, Marco, Della Monica, Emanuele, Rivetti, Claudio, Antin, Parker B, Bettati, Stefano, Steiner, Roberto A, Percudani, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517255/
https://www.ncbi.nlm.nih.gov/pubmed/37695804
http://dx.doi.org/10.1093/molbev/msad200

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