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Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease

BACKGROUND: Little research exists on how individual risk factors for Alzheimer’s disease (AD) affect the intermediate phenotype after transcranial direct current stimulation (tDCS), despite the importance of precision medicine-based therapeutic approaches. OBJECTIVE: To determine how an application...

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Autores principales: Kang, Dong Woo, Wang, Sheng-Min, Um, Yoo Hyun, Kim, Sunghwan, Kim, TaeYeong, Kim, Donghyeon, Lee, Chang Uk, Lim, Hyun Kook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517264/
https://www.ncbi.nlm.nih.gov/pubmed/37744398
http://dx.doi.org/10.3389/fnagi.2023.1234086
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author Kang, Dong Woo
Wang, Sheng-Min
Um, Yoo Hyun
Kim, Sunghwan
Kim, TaeYeong
Kim, Donghyeon
Lee, Chang Uk
Lim, Hyun Kook
author_facet Kang, Dong Woo
Wang, Sheng-Min
Um, Yoo Hyun
Kim, Sunghwan
Kim, TaeYeong
Kim, Donghyeon
Lee, Chang Uk
Lim, Hyun Kook
author_sort Kang, Dong Woo
collection PubMed
description BACKGROUND: Little research exists on how individual risk factors for Alzheimer’s disease (AD) affect the intermediate phenotype after transcranial direct current stimulation (tDCS), despite the importance of precision medicine-based therapeutic approaches. OBJECTIVE: To determine how an application of sequential tDCS (2 mA/day, left dorsolateral prefrontal cortex, 10 sessions) affects changes in white matter (WM) microstructure integrity in 63 mild cognitive impairment (MCI) patients with effect modifiers such as Aβ deposition, APOE ε4 carrier status, BDNF Val66Met polymorphism status, and sex. METHODS: We examined individual effect modifier-by-tDCS interactions and multiple effect modifiers-by-tDCS interactions for diffusion metrics. We also evaluated the association between baseline Aβ deposition and changes in WM microstructure integrity following tDCS. RESULTS: We found that APOE ε4 carrier status and sex had a significant interaction with tDCS, resulting in increased fractional anisotropy (FA) in the right uncinate fasciculus (UF) after stimulation. Additionally, we observed multiple effect modifiers-by-tDCS interactions on WM integrity of the right UF, leading to a more pronounced increase in FA values in APOE ε4 carriers and females with Val66 homozygotes. Finally, baseline Aβ deposition was positively associated with a difference in FA of the left cingulum in the hippocampal area, which showed a positive association with the changes in the score for delayed memory. CONCLUSION: Our study shows the differential impact of individual AD risk factors on changes in the early intermediate phenotype after sequential tDCS in MCI patients. This research emphasizes the importance of precision medicine approaches in tDCS for the prodromal stages of AD.
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spelling pubmed-105172642023-09-24 Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease Kang, Dong Woo Wang, Sheng-Min Um, Yoo Hyun Kim, Sunghwan Kim, TaeYeong Kim, Donghyeon Lee, Chang Uk Lim, Hyun Kook Front Aging Neurosci Aging Neuroscience BACKGROUND: Little research exists on how individual risk factors for Alzheimer’s disease (AD) affect the intermediate phenotype after transcranial direct current stimulation (tDCS), despite the importance of precision medicine-based therapeutic approaches. OBJECTIVE: To determine how an application of sequential tDCS (2 mA/day, left dorsolateral prefrontal cortex, 10 sessions) affects changes in white matter (WM) microstructure integrity in 63 mild cognitive impairment (MCI) patients with effect modifiers such as Aβ deposition, APOE ε4 carrier status, BDNF Val66Met polymorphism status, and sex. METHODS: We examined individual effect modifier-by-tDCS interactions and multiple effect modifiers-by-tDCS interactions for diffusion metrics. We also evaluated the association between baseline Aβ deposition and changes in WM microstructure integrity following tDCS. RESULTS: We found that APOE ε4 carrier status and sex had a significant interaction with tDCS, resulting in increased fractional anisotropy (FA) in the right uncinate fasciculus (UF) after stimulation. Additionally, we observed multiple effect modifiers-by-tDCS interactions on WM integrity of the right UF, leading to a more pronounced increase in FA values in APOE ε4 carriers and females with Val66 homozygotes. Finally, baseline Aβ deposition was positively associated with a difference in FA of the left cingulum in the hippocampal area, which showed a positive association with the changes in the score for delayed memory. CONCLUSION: Our study shows the differential impact of individual AD risk factors on changes in the early intermediate phenotype after sequential tDCS in MCI patients. This research emphasizes the importance of precision medicine approaches in tDCS for the prodromal stages of AD. Frontiers Media S.A. 2023-09-01 /pmc/articles/PMC10517264/ /pubmed/37744398 http://dx.doi.org/10.3389/fnagi.2023.1234086 Text en Copyright © 2023 Kang, Wang, Um, Kim, Kim, Kim, Lee and Lim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Kang, Dong Woo
Wang, Sheng-Min
Um, Yoo Hyun
Kim, Sunghwan
Kim, TaeYeong
Kim, Donghyeon
Lee, Chang Uk
Lim, Hyun Kook
Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title_full Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title_fullStr Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title_full_unstemmed Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title_short Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
title_sort impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for alzheimer’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517264/
https://www.ncbi.nlm.nih.gov/pubmed/37744398
http://dx.doi.org/10.3389/fnagi.2023.1234086
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