Leishmania major centrin knock-out parasites reprogram tryptophan metabolism to induce a pro-inflammatory response

Leishmaniasis is a parasitic disease that is prevalent in 90 countries, and yet no licensed human vaccine exists against it. Toward control of leishmaniasis, we have developed Leishmania major centrin gene deletion mutant strains (LmCen(−/−)) as a live attenuated vaccine, which induces a strong IFN-...

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Detalles Bibliográficos
Autores principales: Oljuskin, Timur, Azodi, Nazli, Volpedo, Greta, Bhattacharya, Parna, Markle, Hannah L., Hamano, Shinjiro, Matlashewski, Greg, Satoskar, Abhay R., Gannavaram, Sreenivas, Nakhasi, Hira L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517402/
https://www.ncbi.nlm.nih.gov/pubmed/37744403
http://dx.doi.org/10.1016/j.isci.2023.107593

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